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KMID : 0043320120350050785
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Archives of Pharmacal Research
2012 Volume.35 No. 5 p.785 ~ p.789
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New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
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Kim Seung-Ill
Lee Seung-Ho
Lee Eung-Seok
Lee Chong-Soon
Jahng Yurng Dong
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Abstract
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A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
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KEYWORD
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Rutaecarpine, Topoisomerase I, Topoisomerase II, Indoloquinazoline alkaloid
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